For IIS versions higher than 7.0 there is an extra setting needed to make sure your ISAPI module can be loaded by the IIS server. To adjust this setting, open IIS Manager and select ISAPI and CGI Restrictions for the root server.
ISAPI and CGI Restrictions
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Option: Allow all unspecified ISAPI modules
Double-click on the ISAPI and CGI Restrictions icon to open the feature.
ISAPI and CGI Restrictions view
To enable all ISAPI modules by default, select Edit Feature Settings... and check Allow unspecified ISAPI modules.
Allow unspecified ISAPI modules
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Option: Add ISAPI modules individually
If you prefer to add modules one by one, click Add and register each ISAPI module manually.